Treatment of Chloroquine-Resistant Plasmodium vivax with Chloroquine and Primaquine or Halofantrine

Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.

Optimal therapy for infection by chloroquine-resistant Plasmodium vivax has not been established. From 1992 to 1994 during three separate studies, 147 Javanese residents of Irian Jaya infected by P. vivax were treated with either chloroquine (25 mg of base/kg during 3 days or 10 mg of base/kg in one dose) plus primaquine (10 mg/kg during 28 days or 2.5 mg/kg during 3 days) (n = 78), chloroquine...

Chloroquine-Resistant Plasmodium vivax, Brazilian Amazon

To the Editor: Plasmodium vivax is the protozoan that causes the second most common form of malaria. Some resistant strains to chloroquine (CQ) occur in a few places in Asia and the Indo-Pacifi c Region (1–4). Although resistance of P. vivax to CQ has already been described in South Ameri-ca (5–7), there are limited data regarding this issue. CQ plus primaquine is the standard treatment for viv...

Therapeutic responses of Plasmodium vivax malaria to chloroquine and primaquine treatment in northeastern Myanmar.

Chloroquine-primaquine (CQ-PQ) continues to be the frontline therapy for radical cure of Plasmodium vivax malaria. Emergence of CQ-resistant (CQR) P. vivax parasites requires a shift to artemisinin combination therapies (ACTs), which imposes a significant financial, logistical, and safety burden. Monitoring the therapeutic efficacy of CQ is thus important. Here, we evaluated the therapeutic eff...

Chloroquine resistance in Plasmodium vivax.

Chloroquine-resistant Plasmodium vivax in Pakistan: an emerging threat.

Pakistan has a population of 194 million people, of which approximately 182 million live in malaria-endemic regions. In Pakistan there are 500 000 new cases of malaria and 50 000 deaths caused by malaria each year. Plasmodium vivax is the culprit in 88% of malaria admissions, although Plasmodium falciparum often takes the spotlight, given its more severe course. Chloroquine has long been the dr...